What are Fibroblasts?

A fibroblast is a type of cell that is responsible for making the extracellular matrix and collagen.

Together, this extracellular matrix and collagen form the structural framework of tissues in animals and plays an important role in tissue repair. Fibroblasts are the main connective tissue cells present in the body.

Wound healing and the role of fibroblasts.

Fibroblasts are critical in supporting normal wound healing, involved in key processes such as breaking down the fibrin clot, creating a new extracellular matrix (ECM) and collagen structures to support the other cells associated with effective wound healing, as well as contracting the wound. This article explores and summarises the research evidence on the role of fibroblasts, their origins and activation, and how they navigate the wound bed, as well as how their activity leads to wound contraction. This article also explores the local conditions at the wound site, which activate, regulate and ultimately reduce the fibroblast activity as the skin’s integrity returns on healing.

As well as being present as fibroblasts, these cells exist in an alternative state, as fibrocytes. The fibroblast is the term used to describe these cells when they are in an activated state. Fibrocyte refers to the less active state when the cell is involved in tissue maintenance and metabolism. Some researchers use the term fibroblast for both cellular states but the term “blast” usually refers to a stem cell or a cell’s activated state.

The appearance of fibroblasts changes depending on their function and site of action. Fibroblasts taken from a particular location can “remember” their original location and function when transplanted to another location in the body.

Fibroblast origin

The primary function of fibroblasts is the maintenance of structural integrity within the connective tissue. They achieve this by secreting extracellular matrix precursors required for formation of the connective tissue and various fibers.

Fibroblasts are originally derived from primitive mesenchyme and therefore display the filament protein vimentin, which acts as a marker of mesodermal origin. In some cases, epithelial cells may also produce fibroblasts, a process which is referred to as epithelial-mesenchymal transition (EMT). Conversely, fibroblasts sometimes undergo a mesenchymal-epithelial transition (MET) to produce epithelia, a process that is seen in development, tissue repair, and tumor growth.


Fibroblast is an innovative treatment with results which you would normally only expect after surgery but there are no scalpels and no suturing involved. The treated area is sublimated (converted directly to vapor) using the plasma beam without damage to the deep skin or muscle.


  • Non-surgical rejuvenation
  • Virtually pain-free treatment
  • No injectable anesthetic required
  • No cutting of skin or stitches required
  • Minimal side effects and downtime
  • Instant & amazing results


– Non-surgical blepharoplasty – skin tightening of saggy upper and lower eyelids

– Skin lesions such as moles, skin tags, fibromas, warts, papillomas, and xanthelasma, seborrheic keratosis

-Unwanted wrinkles on face – frown lines, crow’s feet, smoker’s lines, necklines etc.

– Skin pigmentation, age spots on face or hands, sun spots, melasma, chloasma, freckles

– Scarring including stretch marks, acne scars, and post-surgical scars

What can I expect after my Fibroblast plasma treatment?

Final results after Plexr depend on the severity of skin laxity or size of the lesion, the desired result, the general condition of the skin and any pre-existing skin or medical problems. Reduction in skin folds and creases appear immediately. The tiny dark brown spots flake off over the following two to three weeks and the skin will heal within a similar period. Swelling is common and can be quite pronounced around the eyes, often worse the following morning and lasting for several days. The area may be tender as it is healing and may scab. It is important to allow any spots or scabs to fall off naturally otherwise scarring or infection may occur. As the treated skin is sublimated, the results often last years or permanently.


If you’re interested in Fibroblast Plasma Skin Tightening, schedule a complimentary consultation today. You can email us at, you can also book online at or Call us at (509) 572-2777

For more Fibroblasting Tips, join our Facebook group Fibroblast USA Professional Group

Link here –> Fibroblast USA Professional Group

You can also join our other Facebook groups:

Flash Your Style Page

👩‍💻Social Media Lash Tips🤳💄

Fibroblast USA Professional Group

Online Microblading & Fibroblast Training Worldwide Flash Your Style

Online Microblading & Fibroblasting Training WorldWide